- Steve Carell Character (Gru)
- Kristen Wiig Character (Lucy)
- Benjamin Bratt Character (Eduardo/ El Macho)
- Miranda Cosgrove Character (Margo)
- Russell Brand Character (Dr. Nefario)
- Ken Jeong Character (Floyd)
- Steve Coogan Character (Silas)
- Elsie Kate Fisher Character (Agnes)
- Dana Gaier Character (Edith)
- Moiss Arias Character (Antonio)
- Nasim Pedrad Character (Jillian)
- Kristen Schaal Character (Shannon)
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